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. 2015 Sep 18;10(9):e0137955. doi: 10.1371/journal.pone.0137955

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© 2015 Matsuoka et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 1 — Schematic representation of RORα and C/EBP binding sites (RORE, C1, C2, C3, C4, and C5) in human PEPCK. The nucleic acid sequence is shown, with binding sites underlined and conserved sequences marked with asterisks. Mutations used in luciferase reporters are indicated with arrowheads. RORα and C/EBPβ regulate gene expression, mainly by binding their respective response elements.