Fig 2. The mutant frequency of Mycobacterium tuberculosis H37Rv growing at either a fast growth rate or a slow growth rate in response to isoniazid exposure.

The mutant frequency of Mycobacterium tuberculosis H37Rv growing at either a fast growth rate (Panel A, solid lines; circles: Culture INH23.2 & triangles: Culture INH23.3) or a slow growth rate (Panel B solid lines; circles: Culture INH69.2 & triangles: Culture INH69.3) for at least 7 MGT in response to isoniazid (0.5 mg L^-1) added at 0h and continuously throughout culture. Each line represents the mutant frequency from an individual chemostat culture. The dotted lines in each case are control cultures without isoniazid addition