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. Author manuscript; available in PMC: 2015 Sep 18.
Published in final edited form as: ChemMedChem. 2011 Jan 21;6(2):334–342. doi: 10.1002/cmdc.201000490

Scheme 1.

Scheme 1

Reagents and conditions: a) (CH3)3SiCl/NaI/CH3CN, CH3CN, RT→60°C, 24 h, 57%; b) tBuOK, tBuOH, THF, 70°C, 1–2.5 h, 26–92 %; c) Benzimidazole-2-acetonitrile, CH3COONH4, neat or toluene, 150 °C, 0.5–1.5 h, 51–91 %; d) for 4: TeO2/H2O2, MeOH/H2O, RT, 72 h, 66%; for 5: m-CPBA, acetone, RT, 3 h; e) BBr3, CH2Cl2, 0°C!RT, 2 h, 79%. For complete structures see Figure 1.