Table 3.
Metabolic stability of selected compounds in mouse liver microsomes.
| Compd | Half life [min] | Qp,h [%][a] |
|---|---|---|
| 3a | 6.50 | 95.4 |
| 3d | 14.96 | 90.0 |
| 3e | 9.43 | 93.5 |
| 3v | 7.82 | 94.5 |
| 3w | 51.21 | 72.5 |
[a]
Percentage ratio of predicted clearance over plasma flow.
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