Table 4.
Quantitative RT-PCR analysis with Taqman miRNA probes verified 11 miRNAs with a higher rank alteration in miRNA PCR array from the sildenafil-upregulated or -downregulated group.
miRNA Name | miRNA PCR Array | qRT-PCR Taqman Assay | miRNA PCR Array | qRT-PCR Taqman Assay | ||||
---|---|---|---|---|---|---|---|---|
CSPGs vs control (n=4/group) |
p-value | CSPGs vs control (n=3/group) |
p-value | sildenafil +CSPGs vs CSPGs (n=4/group) |
p-value | sildenafil +CSPGs vs CSPGs (n=3/group) |
p-value | |
miR-105 | −26.0 | 0.017 | −1.7 | 0.375 | 9.0 | 0.000 | −1.2 | 0.567 |
miR-298-5p | −11.7 | 0.007 | −11.1 | 0.036 | 4.3 | 0.002 | 1.8 | 0.026 |
miR-511-5p | −7.7 | 0.001 | − 1.1 | 0.919 | 5.5 | 0.004 | 1.4 | 0.512 |
miR-339-5p | −8.8 | 0.055 | −5.9 | 0.026 | 3.7 | 0.042 | 1.5 | 0.047 |
miR-34a-5p | −8.6 | 0.019 | −4.8 | 0.031 | 2.4 | 0.011 | 2.2 | 0.012 |
miR-381-3p | −6.2 | 0.014 | Undetectable | N/A | 2.7 | 0.060 | Undetectable | N/A |
miR-19a-3p | 2.8 | 0.001 | −2.9 | 0.004 | −3.0 | 0.001 | −1.5 | 0.111 |
miR-376b-3p | 2.9 | 0.012 | 1.6 | 0.048 | −2.1 | 0.016 | −3.4 | 0.023 |
miR-20b-5p | 1.9 | 0.001 | 5.9 | 0.012 | −2.4 | 0.001 | −12.5 | 0.013 |
miR-20a-5p | 1.9 | 0.005 | 1.2 | 0.027 | −2.3 | 0.011 | −4.5 | 0.004 |
miR-29c-3p | 1.6 | 0.003 | 2.6 | 0.011 | −2.5 | 0.019 | −14.3 | 0.001 |
Numbers are fold changes.