Table 3.
Changes in blood chemistry
| Variable | Placebo (n=15) |
HCQ (n=17) |
p value (HCQ vs placebo) |
Difference (HCQ vs placebo) |
95% CI |
|---|---|---|---|---|---|
| Fasting glucose (mmol/l) | |||||
| Baseline | 5.16±0.49 | 5.47±0.79 | 0.20 | ||
| Change from baseline | +0.07±0.09 | −0.22±0.10 | 0.04 | −0.30±0.14 | (−0.58, −0.02) |
| Fasting HbA1c (%) | |||||
| Baseline | 5.65±0.41 | 5.72±0.35 | 0.60 | ||
| Change from baseline | +0.14±0.04 | +0.03±0.03 | 0.03 | −0.11±0.05 | (−0.21, −0.03) |
| Fasting insulin (pmol/l) | |||||
| Baseline | 61.1±61.0 | 66.7±37.5 | 0.77 | ||
| Change from baseline | +7.0±7.0 | +16.0±7.0 | 0.34 | 9.0±9.7 | (−9.8, 28.5) |
| Fasting NEFA (µmol/l) | |||||
| Baseline | 509±150 | 538±132 | 0.59 | ||
| Change from baseline | −31±32 | −74±35 | 0.38 | −43±48 | (−14.6, 5.5) |
| Fasting C-peptide (nmol/l) | |||||
| Baseline | 1.32±0.67 | 1.27±0.48 | 0.82 | ||
| Change from baseline | +0.01±0.08 | +0.18±0.09 | 0.16 | 0.17±0.12 | (−0.08, 0.42) |
| C-peptide/insulin molar ratio (pmol/pmol) | |||||
| Baseline | 31.4±17.1 | 29.2±20.3 | 0.76 | ||
| Change from baseline | −5.5±3.3 | −4.8±3.6 | 0.88 | 0.8±4.9 | (−9.4, 10.9) |
Baseline values are expressed as means ± SD. Changes from baseline are expressed as means ± SE adjusted for baseline (ANCOVA)