Table 1. Descriptive statistics.

This table describes basic features of the participating studies.

Study	PPMI			PDBP		PARS			23AndMe		LABS-PD		Penn-Udall
Status within study	Case	Control	SWEDD	Case	Control	Case	Control	At risk	Case	Control	Case	SWEDD	Case
Participants (N)	367	165	55	453	156	15	85	146	20	20	239	13	98
Female (%)	33.2	33.3	34.5	40.4	50	33.3	54.1	52.0	45.0	55.0	35.1	61.5	31.6
Age (mean, SD)	64.256, 9.598	63.794, 10.588	63.018, 10.117	64.936, 9.046	62.301, 10.958	67.400, 6.909	63.467, 10.269	64.290, 8.338	52.650, 9.959	60.150, 10.148	59.127, 9.075	60.041, 12.927	63.816, 8.813
Family History (%)	25.1	5.4	30.9	25.4	10.9	66.6	43.5	43.8	25.0	25.0	26.8	38.5	29.6
Total UPSIT score (mean, SD)	22.196, 8.261	34.345, 4.372	32.181, 5.754	19.984, 7.959	32.590, 5.924	17.667, 5.827	35.118, 3.311	22.897, 6.283	20.550, 7.067	33.050, 3.634	19.422, 7.591	28.692, 8.420	18.316, 6.929
GRS in Z units (mean, SD)	0.595, 1.201	0, 1	0.347, 1.065	0.600, 1.229	0.094, 1.030	0.685, 0.912	0.140, 1.071	0.263, 1.070	0.531, 1.471	−0.159, 0.936	0.625, 1.114	0.328, 0.668	0.398, 1.189
Diagnostic criteria	UK Brain Bank criteria for PD plus DaT scanning showing dopaminergic dysfunction at baseline	No clinical indication of PD	UK Brain Bank criteria for PD plus DaT scanning showing normal dopaminergic function at baseline	UK Brain Bank criteria for PD	No clinical indication of PD	UK Brain Bank criteria for PD	No clinical indication of PD	No clinical indication of PD but some degree of hyposmia	Self-report of PD diagnosis	Self-report of neurologically normal status	UK Brain Bank criteria for PD plus DaT scanning showing dopaminergic dysfunction at baseline	UK Brain Bank criteria for PD plus DaT scanning showing normal dopaminergic function at baseline	UK Brain Bank criteria for PD