Table 1.

Dalbavancin MICs for several gram-positive organisms [15–18, 25–27]

	Number of isolates	MIC50 (µg/ml)	MIC90 (µg/ml)	Range	% Susc.
S. aureus [15–18, 25, 27]	64,843	0.06	0.06	≤0.008 to 0.5	99.7
MSSA [15–18, 25, 27]	37,222	0.06	0.06	≤0.008 to 0.5	99.7
MRSA [15–18, 25, 27]	27,261	0.06	0.06	≤0.008 to 0.5	99.6
hVISA [18]	10	0.25	0.5	0.12 to 0.5	20
VISA [18]	8	0.5	N/A	0.5 to 2	0
DNS SA [25]	37	0.06	0.12	≤0.03 to 0.5	91.9
LR SA [25]	19	0.06	0.12	≤0.03 to 0.5	100
CNS [15, 16, 27]	473	≤0.03	0.06	≤0.03 to 0.25	99.6
MS CNS [15, 16, 27]	281	≤0.03	0.06	≤0.03 to 1	N/A
MR CNS [15, 16, 27]	193	≤0.03	0.12	≤0.03 to 0.25	N/A
Enterococcus spp. [15, 16]	116	0.06	>4	≤0.03 to >4	56
VSE [15, 16]	63	≤0.03	0.12	≤0.03 to 0.25	96.8
VRE [15, 16]	53	>4	>4	≤0.03 to >4	7.5
VanA VRE [15, 16]	49	>4	>4	0.25 to >4	0
VanB VRE [15, 16]	4	≤0.03	0.12	≤0.03 to 0.12	100
E. faecalis [16]	25	0.06	>4	≤0.03 to >4	76
VSE faecalis [16]	19	≤0.03	0.06	≤0.03 to 0.06	100
VRE faecalis [16]	6	>4	>4	>4	0
E. faecium [16]	31	1	>4	≤0.03 to >4	41.9
VSE faecium [16]	11	0.06	0.12	≤0.03 to 0.12	100
VRE faecium [16]	20	>4	>4	≤0.03 to >4	10
β-hemo strep [15, 16, 26]	1242	≤0.03	≤0.03	≤0.03 to 0.25	98.6
Viridans strep [15, 16, 26]	786	≤0.03	≤0.03	≤0.03 to 0.25	99.7
S. anginosus [26]	190	≤0.03	≤0.03	≤0.03 to 0.06	100
S. milleri [26]	14	≤0.03	≤0.03	≤0.03 to 0.06	100
S. bovis [26]	47	≤0.03	0.06	≤0.03 to 0.12	100
S. dysgalactiae [26]	50	≤0.03	0.06	≤0.03 to 0.12	100
S. mitis [26]	305	≤0.03	0.06	≤0.03 to 0.25	99.7
S. mutans [26]	20	≤0.03	0.06	≤0.03 to 0.12	100
S. salivarius [26]	49	≤0.03	0.06	≤0.03 to 0.25	98
GAS [15, 16, 26]	506	≤0.03	≤0.03	≤0.03 to 0.12	100
GBS [15, 16, 26]	287	≤0.03	0.12	≤0.03 to 0.25	94.4
S. pneumoniae [27]	893	≤0.03	≤0.03	≤0.03 to 0.12	100
PSSp [27]	739	≤0.03	≤0.03	≤0.03 to 0.12	100
PISp [27]	120	≤0.03	≤0.03	≤0.03 to 0.12	100
PRSp [27]	34	≤0.03	≤0.03	≤0.03	100

SA S. aureus, MS methicillin-susceptible, MR methicillin-resistant, DNS daptomycin-nonsusceptible, LR linezolid-resistant, CNS coagulase-negative staphylococci, VSE vancomycin-susceptible enterococci, VRE vancomycin-resistant enterococci, GAS group A streptococci, GBS group B streptococci, Sp S. pneumo, PS penicillin-susceptible, PI penicillin-intermediate, PR penicillin-resistant