Table 2.
Frequency of HIV symptoms by study visit in the switch and no-switch groups
| Switch group baseline (%) N = 286 |
No-switch group baseline (%) N = 135 |
Switch group week 4 (%) N = 280 |
No-switch group week 4 (%) N = 124 |
Switch group week 48 (%) N = 259 |
No-switch group week 48 (%) N = 117 |
|
|---|---|---|---|---|---|---|
| Fatigue/loss of energy | 35.7 | 42.2 | 34.5 | 34.9 | 33.6 | 33.3 |
| Difficulty sleeping | 31.5 | 29.6 | 28.1 | 34.1 | 29.4 | 27.5 |
| Nervous/anxious | 30.4 | 28.9 | 22.1** | 27.1 | 26.0 | 20.8 |
| Diarrhea/loose bowels | 29.0 | 27.4 | 13.5***,^^^ | 31.0^^^ | 11.3***,^^^ | 25.8^^^ |
| Changes in body composition | 28.3 | 25.9 | 18.5*** | 24.8 | 23.4* | 20.0 |
| Sad/down/depressed | 27.6 | 23.7 | 24.6 | 26.4 | 25.3 | 25.0 |
| Bloating/pain/gas in stomach | 26.2 | 23.7 | 18.5**,^^ | 31.0^^ | 20.0* | 24.2 |
| Muscle aches/joint pain | 25.5 | 25.2 | 17.1** | 21.7 | 20.4 | 18.3 |
| Problems with sex | 25.5 | 20.0 | 20.3* | 20.2 | 20.8 | 21.7 |
| Trouble remembering | 20.6 | 25.9 | 18.9 | 24.8 | 24.9 | 24.2 |
| Headaches | 18.9 | 20.7 | 16.0 | 13.2* | 17.4 | 11.7* |
| Pain/numbness/tingling in hands/feet | 18.9 | 19.3 | 12.5**,^ | 20.9^ | 17.7 | 18.3 |
| Skin problems/rash/itching | 17.1 | 17.0 | 15.3 | 14.7 | 18.9 | 16.7 |
| Cough/trouble breathing | 15.0 | 11.1 | 13.5 | 10.9 | 11.3 | 12.5 |
| Fever/chills/sweats | 14.0 | 13.3 | 8.2** | 7.0* | 9.1* | 8.3 |
| Dizzy/lightheadedness | 11.9 | 16.3 | 13.2 | 12.4 | 10.9 | 11.7 |
| Weight loss/wasting | 11.5 | 14.1 | 10.0 | 5.4** | 9.4 | 7.5 |
| Nausea/vomiting | 11.2 | 5.9 | 7.5 | 5.4 | 6.4 | 7.5 |
| Hair loss/changes | 10.1 | 11.1 | 8.2 | 12.4 | 13.6 | 12.5 |
| Loss of appetite/food taste | 5.9 | 5.9 | 7.8 | 3.1 | 7.9 | 5.8 |
* p < 0.05, ** p < 0.01, *** p < 0.001 McNemar test within group for change from baseline
^ p < 0.05, ^^ p < 0.01, ^^^ p < 0.001 Chi square test between group differences