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. 2015 Sep 10;130(4):511–523. doi: 10.1007/s00401-015-1475-3

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© The Author(s) 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 5 — Intraneuronal deposits are of endolysosomal origin. 18-month CHMP2B^Intron5 mouse brains were prepared for pre-embedding immuno-EM. Neuronal deposits stained positively for LAMP-1 (a, b) or LAMP-2 (c, d), but not for p62 (e), although p62-positive structures could be observed in oligodendrocytes (f). Nu nucleus. Scale bars 1 μm