Fig. 7.

Autofluorescent aggregates are a characteristic pathology of FTD-3 patient brain. Autofluorescent pathology in frontal cortex tissue from FTD-3, AD and neurologically normal control brains was investigated. a Examples of an autofluorescent aggregate in FTD-3 patient frontal cortex, and the morphologically distinct granular lipofuscin in control cortex. DAPI labels the nuclei (blue). b Blinded quantification of the coverage of autofluorescent aggregates or lipofuscin per field of view in control, AD or FTD-3 patient frontal cortex. Percentage of either neurons or microglia containing autofluorescence (c) or lipofuscin (d). Data are shown as individual symbols per case with bars representing mean ± SEM. Closed symbols autofluorescent aggregates, open symbols lipofuscin. Significance was determined using a one-way ANOVA, with post hoc Bonferroni test. *p < 0.05, **p < 0.01, ***p < 0.001. All statistically significant differences are shown