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. 2015 Sep 18;12:19. doi: 10.1186/s12976-015-0011-4

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© Rodríguez et al. 2015

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 8 — CHKREC components activation in normal and FA cells. After DNA damage induction, the cell activates the DNA damage integrity checkpoints, the G2/M checkpoint specifically avoids the transition of the cell from G2 to M phase with unrepaired DNA damage. Once the DNA has been repaired, the G2/M checkpoint is satisfied and the cell activates the CHKREC, a process that inactivates checkpoint proteins and promotes cell division. Upper panel. Normal cells activate CHKREC with repaired chromosomes. Bottom panel. FA cells activate CHKREC despite unrepaired chromosomes. The specific mechanism triggering this inappropriate CHKREC activation in FA cells remains unknown