Table 1.

Boolean functions for the nodes in the FA/BRCA network

RULES	REFERENCES
ICL ← ICL ∧¬ DSB	[38]
FAcore ← ICL ∧ (ATR ∨ ATM) ∧¬ CHKREC	[14, 16, 44–46]
FANCD2I ← FAcore ∧ ((ATR ∨ ATM) ∨ ((ATR ∨ ATM) ∧ DSB)) ∧	[47–49]
¬ (CHKREC)
NUC1 ←ICL ∧ FANCD2I	[50]; [38]
NUC2 ← (ICL ∧ (ATR ∨ ATM) ∧¬ (FAcore ∧ FANCD2I)) ∨	[51]; [38]
(ICL ∧ NUC1 ∧ p53 ∧¬(FAcore ∧ FANCD2I))
ADD ← (NUC1 ∨ NUC2 ∨ (NUC1 ∧ NUC2)) ∧¬ (TLS)	[47, 50, 51]
DSB ← (NUC1 ∨ NUC2) ∧¬ (NHEJ ∨ FAHRR ∨ HRR2)	[50, 52]
TLS ← (ADD ∨ (ADD ∧ FAcore)) ∧¬ (CHKREC)	[53, 54]
FAHRR ← DSB ∧ FANCD2I ∧¬ (NHEJ ∧ CHKREC)	[53, 54]
HRR2 ← (DSB ∧ NUC2 ∧ NHEJ ∧ ICL ∧¬ (FAHRR ∨ CHKREC)) ∨	[38]
(DSB ∧ NUC2 ∧ TLS ∧¬ (NHEJ ∨ FAHRR ∨ CHKREC))
NHEJ ← (DSB ∧ NUC2 ∧¬ (FAHRR ∨ HRR2 ∨ CHKREC))	[49, 52, 55–57]
ATR ←(ICL ∨ ATM) ∧¬ CHKREC	[58–60]
ATM ← (ATR ∨ DSB) ∧¬ CHKREC ∨ FAcore	[61, 62]
P53 ← ((ATR ∨ ATM) ∨ NHEJ) ∧¬ CHKREC	[58, 63, 64]
CHKREC ← ((TLS ∨ NHEJ ∨ FAHRR ∨ HRR2) ∧¬ DSB) ∨	[52, 53];
((¬ ADD) ∧ (¬ ICL) ∧ (¬ DSB) ∧¬ (CHKREC))	[38, 65]

Key references are included. Full discussion of interactions can be found in [38]