Table 2.
Network model simplification criteria
| Node in the | Nodes in the | Simplification criteria | |
|---|---|---|---|
| original BNM | simplified BNM | ||
| ICL | ICL | Unchanged node | |
| FANCM, FAcore | FAcore | ICL recognition proteins working | |
| together in the upstream FA/BRCA | |||
| pathway | |||
| FANCD2I | FANCD2I | Unchanged node | |
| MUS81 | NUC1 | Nuclease mediated | |
| ICL incision | |||
| XPF, FAN1 | NUC2 | Nuclease mediated | |
| ICL incision | |||
| ADD | ADD | Unchanged node | |
| DSB | DSB | Unchanged node | |
| ATR, CHK1, H2AX | ATR | These proteins act in the | |
| Checkpoint pathway | |||
| ATM, CHK2, H2AX | ATM | These proteins act in the | |
| Checkpoint pathway | |||
| p53 | p53 | Unchanged node | |
| PCNATLS | TLS | This is only a change in name | |
| FANCJMLH1, MRN, BRCA1, | FAHRR | These proteins act in the | |
| FANCD1N, RAD51, HRR, | Homologous Recombination | ||
| ssDNARPA | Repair pathway | ||
| —— | HRR2 | New node representing the | |
| alternative Homologous | |||
| Recombination Repair Pathway | |||
| KU, DNAPK, NHEJ | NHEJ | These proteins act in the | |
| Non-Homologous End-Joining | |||
| DNA repair pathway | |||
| USP1, CHKREC | CHKREC | Global negative regulators | |
| of the FA/BRCA pathway |