Table 2.
Heart Rate Variability from Control (CONTROL) and Chronic Heart Failure Rats Treated or Not with Mesenchymal Stem Cells
| CONTROL (n=9) | CHF (n=10) | CHF+MSC (n=6) | |
|---|---|---|---|
| Time domain | |||
| RR (ms) | 190±4.4 | 187±4 | 195±4.3 |
| SDNN (ms) | 7.7±0.7 | 4.9±0.4* | 6.8±1.3 |
| RMSSD (ms) | 5±0.4 | 3.4±0.4* | 4.7±1 |
| Frequency domain | |||
| LF abs (ms2) | 1.6±0.3 | 0.4±0.1* | 1.6±0.7† |
| HF abs (ms2) | 6.5±1 | 2.3±0.6* | 5.3±1.3† |
| LF/HF | 0.29±0.06 | 0.23±0.03 | 0.32±0.06 |
| Nonlinear methods | |||
| DFA | 1.12±0.01 | 1.18±0.01* | 1.12±0.03† |
| Entropy | 1.32±0.06 | 0.98±0.08* | 1.08±0.15 |
Heart rate variability was examined using linear (time and frequency domain) and nonlinear (DFA and Entropy) methods. ECG recording during 4 h (2 h each day), in conscious animals, provided the data for the analysis of heart rate variability using customized computer software, CardioSeries for linear methods and JBio for nonlinear methods. RR=RR interval, SDNN=standard deviation of normal-to-normal RR intervals, RMSSD, square root of the mean of the squares of differences between adjacent RR intervals; LF and HF=power of the RR spectra in low- and high-frequency bands, DFA=stochastically detrended fluctuation analysis. CONTROL=fictitious ligature of the left coronary artery. The asterisk indicates a statistically significant difference between CHF and CONTROL, *p<0.05; the dagger indicates a statistically significant difference between CHF+MSC and CHF, †p<0.05. Data are expressed as mean±standard error of mean (SEM).