Changes in ICP with time: intervention and control groups. Time 0, prerandomization; Time 1, first hour of hypothermia (<35°C); Time 2, first episode of stable hypothermia (<35°C); Time 3, 6 hours of hypothermia (<35°C). Two-way repeated measures ANOVA demonstrates a difference between the groups F(3,45)=4, p<0.02. ANOVA, analysis of variance.