Table 3.

Multivariate Cox regression models analyzing the associations between nutritional status, as assessed by the GNRI and MNA–SF scores, and overall survival

	GNRI model		MNA–SF model
Parameters	HR (95% CI)	P-value	HR (95% CI)	P-value
Sex
Male	Ref.		Ref.
Female	0.883 (0.638–1.224)	0.637	1.070 (0.771–1.486)	0.684
Age	1.004 (0.971–1.038)	0.836	1.016 (0.982–1.051)	0.366
Charlson Comorbidity Index	0.807 (0.544–1.195)	0.248	0.789 (0.529–1.176)	0.244
Heng risk stratification
Low	Ref.		Ref.
Intermediate	2.601 (1.630–4.148)	<0.001	2.741 (1.724–4.359)	<0.001
High	3.929 (2.155–7.163)	<0.001	5.696 (3.185–10.19)	<0.001
Nephrectomy
No	Ref.		Ref.
Yes	0.560 (0.228–1.378)	0.207	0.492 (0.198–1.222)	0.126
NLR
≤5	Ref.		Ref.
>5	1.541 (0.728–3.264)	0.259	1.266 (0.208–2.638)	0.528
Geographic location
Urban	Ref.		Ref.
Rural	1.506 (1.085–2.091)	0.014	1.696 (1.226–2.346)	0.001
Nutrition risk
Normal	Ref		Ref.
Low	1.502 (1.069–2.498)	0.023	1.320 (0.886–1.967)	0.172
High	3.157 (2.273–5.353)	<0.001	2.784 (1.506–6.065)	0.002
Incremental performance (using Heng model as benchmark)
△ C index	0.041		0.016
IDI at 2 years (95%CI)	0.066 (0.024–0.113)	P = 0.001	0.013 (-0.005-0.050)	P = 0.239
NRI at 2 years (95%CI)	0.177 (0.057–0.363)	P = 0.013	0.123 (-0.134–0.245)	P = 0.286
△ Net benefit at threshold of 50% at 2 years	1.2 per 100 patients		0.9 per 100 patients
△ Net benefit at threshold of 62%* at 2 years	4.5 per 100 patients		2.8 per 100 patients

Abbreviations: GNRI, Geriatric Nutritional Risk Index; MNA–SF, Mini Nutritional Assessment–Short Form; HR, hazard ratio; NLR, neutrophil lymphocyte ratio; C index, Harrell's concordance index; IDI, integrated discrimination improvement index; NRI, net reclassification index

^*For the entire group, 2-year survival rate was 38%.