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. 2015 Apr 27;6(3):237–241. doi: 10.1002/jcsm.12028

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© 2015 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of the Society of Sarcopenia, Cachexia and Wasting Disorders

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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(A) Changes in body weight, muscle mass, and fat mass after treatment with growth hormone releasing peptide-2 (GHRP-2). Fat and muscle mass were evaluated using the bio-impedance method. All parameters gradually increased and the increases of body weight and daily energy intake were −1.5 to 2.4 kg and 12% to 36%, respectively, after ghrelin infusion. (B) Changes in growth hormone (GH) and insulin-like growth factor 1 (IGF-1) levels after treatment with GHRP-2. GH decreased and IGF-1 increased after 12 months. (C) Changes in nutritional status. Retinol binding protein (RBP) and total protein (TP) increased rapidly, and albumin (Alb) increased after 4 months. These parameters further increased after 12 months. (D) Changes in acyl ghrelin (AG) and des-acyl ghrelin (DAG) levels after the administration of GHRP-2. Fasting DAG and AG increased and DAG/AG ratio was lowered after 10 months. BW; body weight.