Table 5.
Association between baseline hormones and incident sarcopenia
| Incident sarcopenia by IWGS |
Incident sarcopenia by EWGSOP |
|||
|---|---|---|---|---|
| OR (95%CI) |
||||
| Unadjusted | Adjusteda | Unadjusted | Adjusteda | |
| Total T (per SD) | 1.54 (0.97, 2.44) | 1.41 (0.80, 2.47) | 0.75 (0.34, 1.68) | 0.78 (0.31, 1.95) |
| Free T(per SD) | 0.82 (0.48, 1.37) | 1.19 (0.58, 2.45) | 0.46 (0.22, 0.96)* | 0.69 (0.24, 1.97) |
| Total E2 (per SD) | 0.86 (0.50, 1.49) | 0.98 (0.53, 1.80) | 1.06 (0.52, 2.18) | 1.11 (0.47, 2.64) |
| Free E2 (per SD) | 0.58 (0.31, 1.08) | 0.83 (0.43, 1.62) | 0.86 (0.40, 1.88) | 1.06 (0.46, 2.47) |
| SHBG (per SD) | 1.78 (1.28, 2.48)** | 1.62 (1.00, 2.64) | 1.50 (0.97, 2.34) | 1.25 (0.61, 2.56) |
| IGF-1 (per SD) | 0.78 (0.44, 1.38) | 0.89 (0.49, 1.63) | 0.26 (0.09, 0.76)* | 0.29 (0.07, 1.18) |
| 25OHD (per SD) | 1.80 (1.11, 2.92)* | 1.60 (0.95, 2.72) | 2.08 (1.12, 3.84)* | 1.91 (0.91, 4.01) |
| 1.25(OH)2D (per SD) | 0.98 (0.50, 1.92) | 0.62 (0.25, 1.53) | 1.69 (0.62, 4.62) | 1.75 (0.50, 6.06) |
| PTH (per SD) | 0.76 (0.42, 1.35) | 0.80 (0.40, 1.60) | 0.79 (0.35, 1.81) | 0.98 (0.40, 2.38) |
BMI, body mass index; CI, confidence interval; E, oestradiol; EWGSOP, European Working Group on Sarcopenia in Older People; IGF-1, insulin-like growth factor-1; IWGS, International Working Group on Sarcopenia; OR, odds ratio; PTH, parathyroid hormone; SD, standard deviation; SHBG, sex hormone-binding globulin; T, testosterone; 1.25(OH)2D, 1,25-dihydroxyvitamin D; 25OHD, 25-hydroxyvitamin D.
*
P < 0.05.
**
P < 0.01.
***P < 0.001.
a
Adjusted for age, centre, BMI, smoking, and number of comorbidities.