Table 1.

Composition of the diet

	Control		Caloric restricted
	g%	Kcal%	g%	Kcal%
Protein	12	15	12	15
Carbohydrate	72	76	72	75
Fat	4	9	4	10
Total		100		100
Kcal/g	3.85		3.77

The diets of the control and calorie and macronutrient-restricted animals were the same, except for the fact that the diet of the restricted animals was compensated in micronutrients to such an extent that micronutrient intake was similar between all groups. The small difference in kcal/g provided between control and calorie restricted is due to the fact that the caloric-restricted diet was compensated for mineral and vitamin contents to avoid deficiencies. The complete ingredient list of the diets is provided in Table S1.