Figure 1.

UVB irradiation enhances mechanically evoked sensory function in rats and humans

A, UVB irradiation significantly reduces mechanical withdrawal thresholds in the ipsilateral, treated paw for up to 7 days (two-way ANOVA, **P < 0.01, ***P < 0.001). B, mechanically evoked firing of rat WDR neurones in the deep dorsal horn is enhanced in UVB rats compared to naive rats (paired t test, *P < 0.05, **P < 0.01). C, human pain ratings to low-threshold dynamic mechanical and pinprick stimulation are increased following UVB irradiation (paired t test, ***P < 0.001). D, human mechanical pain thresholds are reduced following UVB irradiation (***P < 0.001)