Figure 4.

Administration of gAd ameliorates HFD-induced metabolic insulin resistance

Each rat was fed a HFD for 4 weeks and then received an i.p. injection of either gAd (0.4 μg (g body wt)⁻¹) or saline followed by a 2 h insulin clamp (3 mU kg⁻¹ min⁻¹) in the absence or presence of compound C or l-NAME. LFD fed rats were used as control. A, time course of glucose infusion rate. B, steady state glucose infusion rate (C: Compound C; L: l-NAME). *P < 0.05 compared with control; ^#P < 0.05 compared with HFD; ^@P < 0.05 compared with gAd + HFD. n = 5–6.