Table 6.

A tentative assignment of the most important regions in the Raman spectrum of blood serum for the discrimination between AD and OD, as determined by the genetic algorithm (GA).

#	GA spectral region (cm−1)	Peak position ( cm−1) +/− 5	Tentative band assignment [22, 23, 27, 55]	Contributions [22, 23, 27, 56, 57]
1	410-672	415, 419, 455, 477, 509, 519, 526 545, 567, 585, 605, 621, 643, 662	υ(C-C), υ(C-S) aliphatic chains δ(C-C) aliphatic chains	Proteins (amino acids: histidine, tryptophan, proline, lysine, glycine); lipids (fatty acids, triglycerides); carbohydrates (fructose, lactose, citric acid, galactosamine, N-acetyl-glucosamine); riboflavin; phosphatidylinositol; phosphoenolpyruvate
2	710-784	718, 744, 757	υ(C-S) aliphatic chains υ(N+(CH3)3) υ(C-C-N+)	Proteins (amino acids: valine, glutamate, phenylalanine, tryptophan); phospholipids; phosphatidylcholine; phosphoenolpyruvate; acetoacetate; coenzyme A; acetyl coenzyme A; D-fructose-6-phosphate; riboflavin; glutathione
3	973-1010	1003	υ(C-C), υ(C-O), Aromatics ring breathing vibration	Proteins (amino acids: phenylalanine, lysine, glutamate); carbohydrates (fructose, lactose, galactosamine, N-acetyl-glucosamine); acetoacetate
4.	1086-1122	1083, 1104, 1126	υ(C-C), (O-P-O), υ( C-O-C), υ(C-S) aromatic	Proteins (phenylalanine, glycine, valine, glutamate, arginine, histidine, proline); carbohydrates (β glucose, galactosamine, N-acetyl-glucosamine); acetyl coenzyme A; acetoacetate; D-fructose-6-phosphate; phosphoenolpyruvate; phospholipids
5	1199-1235	1207,1235	υ(C-C), υ(C-H), υ(C=S), (CH2) wagging vibrations	Proteins (β sheet, Amid III, tryptophan, tyrosine, phenylalanine, glycine, proline); pyruvate
6	1311-1348	1317, 1338	υ(C-(NO2)), υ(C-(SO2)-C)	Proteins (phenylalanine, tryptophan, glycine, valine, serine, glutamate, histidine, proline, lysine, adenine, α helix); carbohydrates (lactose, N-acetyl-glucosamine); phosphoenolpyruvate; glutathione; phospholipids
7	1424-1498	1448	δ(CH2), δ(CH2OH), δ(CH3), υ(C-C)	Proteins (amino acids: valine, lysine, phenylalanine, tryptophan, proline); fatty acids; carbohydrates (fructose, galactosamine); phosphoenolpyruvate; acetoacetate; β-carotene; glutathione
8	1537-1611	1553, 1586	υ(N=N), υ(C=C), υ(C-(NO2)) NH3+	Guanine; tryptophan; proline; lysine; palmitic acid; N-acetyl-glucosamine
9	1649-1800	1657	υ(C=C), υ(C=O)	Proteins; amide I; α helix; phospholipids

^υstretching mode;

^δbending mode;