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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Prostaglandins Other Lipid Mediat. 2015 Mar 23;120:9–16. doi: 10.1016/j.prostaglandins.2015.03.002

Figure 1. Diagram of the interaction between the Renin-Angiotensin System and 20-HETE.

Figure 1

Angiotensinogen is converted to Angiotensin I (Ang I) by the enzyme, renin. Ang I is cleaved by angiotensin-converting enzyme (ACE) to generate the vasoactive Angiotensin II (Ang II). 20-HETE is produced through the metabolism of arachidonic acid (AA) by enzymes of the CYP4A and CYP4F subfamilies. Ang II can also induce synthesis and release of 20-HETE. 20-HETE has also been shown to activate transcription of ACE in endothelial cells (dashed line). This 20-HETE/RAS interaction establishes a mechanism perpetuating Ang II and 20-HETE production.