The systolic pressures of WT and Cyp2c44 KO male mice (grey and black bars, respectively)(8 mice each group) fed diets containing 0.3% NaCl and normal (NK) or high potassium (HK) (1.0 and 2.5% KCL, respectively)(40) for 2 weeks were measured as described (20,22). Shown are average blood pressures ± SE (in mm of Hg) for WT and 2c44 KO mice (grey and black bars, respectively). Calculated from ≥ 30 measurements/animal. Different from: * KO on NK p<10-4, WT on HK p<10-20, KO on HK p<100-100; + WT or KO on HK p<10-22 or HK p<10-100.