Table 1.

Demographic and clinical characteristics and smoking and alcohol exposures by pretreatment serum HPV DNA status

		Pretreatment serum HPV DNA status
	All patients (N=262)	E6 and E7 negative (N=114)	E6 and/or E7 positive (N=148)	P
Age, mean (SD), years	56.5 (9.6)	57.4 (10.4)	55.8 (8.8)	0.191
Age, median, years	55	56.5	54	0.335
Sex				0.604
Male	224 (85.5)	96 (84.2)	128 (86.5)
Female	38 (14.5)	18 (15.8)	20 (13.5)
Race				0.380
White	239 (91.2)	102 (89.5)	137 (92.6)
Other	23 (8.8)	12 (10.5)	11 (7.4)
Subsite				<0.001a
Tongue	127 (48.5)	61 (53.5)	66 (44.6)
Base of tongue	125 (47.7)	43 (37.7)	82 (55.4)
Other oropharynx	10 (3.8)	10 (8.8)	0
Stage				0.004
I–II	20 (7.6)	10 (8.8)	10 (6.8)
III	26 (9.9)	19 (16.7)	7 (4.7)
IV	216 (82.4)	85 (74.6)	131 (88.5)
T category				0.495
1	76 (29.0)	37 (32.5)	39 (26.4)
2	116 (44.3)	45 (39.5)	71 (48.0)
3	41 (15.7)	20 (17.5)	21 (14.2)
4	29 (11.1)	12 (10.5)	17 (11.5)
N category				0.069
0	30 (11.5)	18 (15.8)	12 (8.1)
1–2a	43 (16.4)	23 (20.2)	20 (13.5)
2b	131 (50.0)	52 (45.6)	79 (53.4)
2c–3	58 (22.1)	21 (18.4)	37 (25.0)
Smoking status				0.687
Never smoker	119 (45.4)	54 (47.4)	65 (43.9)
Former smoker	95 (36.3)	38 (33.3)	57 (38.5)
Current smoker	48 (18.3)	22 (19.3)	26 (17.6)
Pack-years of smoking				0.671
≤10	154 (59.0)	65 (57.5)	89 (60.1)
>10	107 (41.0)	48 (42.5)	59 (39.9)
Missing	1	1	0
Alcohol use status				0.159
Never-drinker	69 (26.3)	35 (30.7)	34 (23.0)
Ever-drinker	193 (73.7)	79 (69.3)	114 (77.0)
Grade				0.261
Well or moderately differentiated/keratinizing	77 (34.4)	38 (38.4)	39 (31.2)
Moderately poorly or poorly differentiated/non-keratinizing	147 (65.6)	61 (61.6)	86 (68.8)
Missing	38	15	23
Tumor HPV DNA status				0.011
Negative	27 (19.2)	18 (28.6)	9 (11.5)
Positive	114 (80.9)	45 (71.4)	69 (88.5)
Missing	121	51	70

^aFisher’s exact test.