Table 2.

Tumor HPV DNA status and recurrence status by pretreatment serum HPV DNA level (copies/mL)

	Serum HPV DNA level (copies/mL)
	0	0.1 – <10	10 – <100	100 – <1000	≥1000	Pe
All patients (n=262)	114	23	59	47	19
Tumor HPV DNA status
E6a						0.036
Negative	20 (27.0)	2 (16.7)	3 (13.0)	0	2 (25.0)
Positive	54 (73.0)	10 (83.3)	20 (87.0)	21 (100)	6 (75.0)
E7b						0.079
Negative	20 (29.9)	2 (13.3)	2 (7.1)	2 (10.5)	1 (14.3)
Positive	47 (70.2)	13 (86.7)	26 (92.9)	17 (89.5)	6 (85.7)
E6/E7c						0.077
Negative	18 (28.6)	2 (13.3)	4 (13.3)	1 (4.2)	2 (22.2)
Positive	45 (71.4)	13 (86.7)	26 (86.7)	23 (95.8)	7 (77.8)
Recurrence statusd
All patients (N=218)						0.677
No recurrence	78 (83.9)	18 (85.7)	45 (90.0)	37 (92.5)	12 (85.7)
Any recurrence	15 (16.1)	3 (14.3)	5 (10.0)	3 (7.5)	2 (14.3)
E6/E7 tumor positivec						0.173
No recurrence	33 (86.8)	9 (75.0)	21 (87.5)	20 (100)	4 (80.0)
Any recurrence	5 (13.2)	3 (25.0)	3 (12.5)	0	1 (20.0)
E6/E7 tumor negativec						1.0
No recurrence	11 (73.3)	2 (100)	3 (100)	0	2 (100)
Any recurrence	4 (26.7)	0	0	0	0

^aCopies of serum E6 DNA in patients by tumor E6 status (E6-positive tumors may be positive or negative for E7; E6-negative tumors also E7-negative).

^bCopies of serum E7 DNA in patients by tumor E7 status (E7-positive tumors may be positive or negative for E6; E7-negative tumors also E6-negative).

^cCopies of serum DNA refers to the higher of the copy number values for E6 and E7 DNA.

^dIncludes only patients who were treated at MD Anderson.

^eFisher’s exact test.