Skip to main content
. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Nat Immunol. 2015 Aug 24;16(10):1094–1103. doi: 10.1038/ni.3249

Figure 1.

Figure 1

STAT5-regulated Brwd1 expression during B lymphopoiesis. (a) Heat map of Igk and Brwd1 expression presented as change in expression (log2) as a function of B cell development and maturation relative to the pro-B cell stage (ImmGen Consortium). (b) Cultured Rag2−/− pro-B cells were subjected to ChIP-Seq with STAT5 and H3K27me3 specific antibodies as described. Reads were aligned to the Brwd1 gene and are presented as smoothed tag densities. Data are representative of two experiments. (c) Localization of BRWD1 in different flow sorted B cell progenitors from wild-type bone marrow by confocal microscopy. Data are representative of 9 images from two independent experiments.