Table 3.
Serum levels of TNF-α, IL-1β, and IL-6 in control, CP, and CP rats pretreated with 18β-GA
| Parameter | Control | CP | CP + 25 mg GA | CP + 50 mg GA |
|---|---|---|---|---|
| TNF-α (pg/mL) | 34.17 ± 5.02 | 124.33 ± 14.32*** | 62.08 ± 8.79### | 40.19 ± 3.99###$ |
| IL-1β (pg/mL) | 26.75 ± 4.36 | 89.43 ± 13.76*** | 39.34 ± 7.76### | 32.11 ± 6.27### |
| IL-6 (pg/mL) | 39.29 ± 6.58 | 93.69 ± 7.81*** | 65.92 ± 8.94### | 47.01 ± 7.07### |
Data are M ± SD (N = 6)
TNF-α tumor necrosis factor alpha, IL interleukin, CP cyclophosphamide, GA glycyrrhetinic acid, SD standard deviation, vs versus
*** P < 0.001 versus control, ### P < 0.001 versus CP, and $ P < 0.05 versus CP + 25 mg GA group