Table 2.
Brain regions with significant working memory training (WMT)-related increases in mean diffusivity (MD), as assessed by region of interest (ROI) analysis
| Area | x | y | z | t score | Corrected P value (SVC, FDR) | Cluster size (mm3) | Correlation with the improvement in WMT (P, t , r values)* | |
|---|---|---|---|---|---|---|---|---|
| Caudate/putamen | R | 24 | 6 | 18 | 4.72 | 0.018 | 2,042 | (0.596, −0.244, −0.044) |
| DLPFC | L | −37.5 | 43.5 | 21 | 3.82 | 0.022 | 790 | (0.011, 2.398, 0.396) |
| Caudate | L | −12 | 13.5 | 15 | 3.79 | 0.022 | 314 | (0.404, 0.246, 0.044) |
| Substantia nigra (R)/ventral tegmental area | 13.5 | −10.5 | −16.5 | 3.56 | 0.024 | 1,461 | (0.807, −0.879, −0.156) | |
| ACC | R | 7.5 | 22.5 | 48 | 3.51 | 0.024 | 732 | (0.009, 2.486, 0.408) |
| Ventral tegmental area | −1.5 | −9 | −10.5 | 3.01 | 0.031 | 105 | (0.908, −1.359, −0.237) |
Statistical values of simple regression analyses that investigated the association between mean change in MD in each cluster and change in performance on WMT tasks