Fig. 2.

C-Raf null mice have profound bilateral sensorineural deafness. a Plots show representative ABR recordings of wild-type, heterozygous, and null mice. b The typical ABR profile consists of five waves corresponding to the different hearing processing centers: I auditory nerve; II cochlear nucleus; III superior olivary nucleus; IV lateral lemniscus; V inferior colliculus. c Average ABR thresholds for click stimuli in wild-type (n = 9), heterozygous (n = 13) and null mice (n = 4). d ABR thresholds in response to tone-burst stimuli in wild-type (n = 9), heterozygous (n = 13) and null mice (n = 4). Null mice showed severe sensorineural hearing loss. The significance of the differences was evaluated using Student’s t test. ***P < 0.001 versus wild type and ⁺⁺⁺ P < 0.001 versus heterozygous