Table 3.
Locomotion adaptation | Interlimb coordination | Avoidance behavior | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mouse line | No. of steps | No. of missteps | Regular steps (%) | No. of blocks | Block size | Effc. trials (%) | Step time (ms) | CV2 | ||||||
SL 2 | SL 4 | SL 2 | SL 4 | SL 2 | SL 4 | Front–hind | Left–right | |||||||
Pcd | ↑ | ↑ | ↑ | ↓ | ↑ | ↑ | ↓ | ↑ | n | ↓ | ↓ | imp. | imp. | n |
L7-Pp2b | ↑ | ↑ | ↑ | ↓ | ↑ | ↑ | ↓ | ↑ | n | ↓ | ↓ | imp. | imp. | n |
L7-∆y2 | ↑ | ↑ | ↑ | ↓ | ↑ | ↑ | ↓ | ↑ | n | ↓ | n | imp. | imp. | n |
α6-Cacna1a | ↑ | ↑ | ↑ | ↓ | ↑ | ↑ | n | ↑ | n | n | n | imp. | imp. | n |
During perturbed sessions locomotion adaptation and interlimb coordination were severely impaired in all four cerebellar mouse mutant lines. None of the cerebellar mouse lines displayed deficits in avoidance behavior. Significant increases (↑) and decreases (↓) relative to control littermates are indicated; n indicates no significant difference tested with repeated measures ANOVA
SL 2 step length = 2, SL 4 step length = 4, Effc. trials efficient trials, imp. impaired