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. Author manuscript; available in PMC: 2016 Sep 15.
Published in final edited form as: Immunity. 2015 Sep 8;43(3):591–604. doi: 10.1016/j.immuni.2015.08.012

Figure 2. CD8+ T cell activation following onset of plasma viremia.

Figure 2

Longitudinal analysis of CD38 and HLA-DR expression on CD8+ cells after HIV infection. (a) Representative FACS plots gated on CD8+ cells expressing CD38 and HLA-DR. Days following onset of plasma viremia (DFOPV) are indicated (b) Longitudinal dynamics of activated (CD38+HLA-DR+) CD8+ cells for 11 donors in whom samples were available for analysis. (c) Representative relationship between HIV-induced CD8+ cell activation kinetics and contemporaneous viral load. (d) Correlation between time to peak activation and viral load setpoint. (e) Correlation between frequency of activated CD8+ cells at peak activation and viral load set point. Spearman’s rank correlation was used in (d) and (e).