TABLE 3.
Representative yields of various HBS helices prepared by the outlined methods.
| HBS helix | Sequencea | % Yieldb |
|---|---|---|
| 9 | XFEA*IYRLELLKAEEAN-NH2 | 20 |
| 10 | XFEG*IYRLELLKAEEAN-NH2 | 25 |
| 11 | XEFL*LRLWLKAibEEAibN-NH2 | 17 |
| 12 | XRKA*YKRLAMK-NH2 | 10 |
| 12 | XQET*FSDLWKLLS-NH2 | Trace |
X denotes 4-pentenoic acid residue, and A*, G*, L* and T* refer to N-aLLyL A, G, L and T residues, respectively.
Amount of the desired helix after HPLC purification.