Table 2.

Examination of predictors of addiction resistance to alcohol, nicotine and cannabis.

Variable	Alcohol		Nicotinea		Cannabis
	Univariate	Multivariate	Univariate	Multivariate	Univariate	Multivariate
FH ALC father	−0.49 ± 0.07****	−0.24 ± 0.07***	−0.26 ± 0.09**	−0.14 ± 0.10	−0.33 ± 0.08****	−0.18 ± 0.08*
FH ALC mother	−0.49 ± 0.13****	−0.10 ± 0.13	−0.18 ± 0.16	+0.13 ± 0.18	+0.17 ± 0.13	+0.02 ± 0.14
FH DA father	−0.78 ± 0.31*	–	−1.04 ± 0.37**	–	−0.73 ± 0.27**	–
FH DA mother	−1.28 ± 0.28****	–	−0.28 ± 0.33	–	−0.83 ± 0.27**	–
Childhood sexual abuse	−0.44 ± 0.09****	−0.12 ± 0.09	−0.14 ± 0.13	+0.07 ± 0.14	−0.32 ± 0.11**	−0.15 ± 0.11
Mean parental warmth (z)	+0.13 ± 0.03****	+0.04 ± 0.03	+0.12 ± 0.04**	−0.04 ± 0.04	+0.15 ± 0.03****	+0.08 ± 0.04*
Lifetime MD	−0.69 ± 0.06****	−0.31 ± 0.07****	−0.50 ± 0.08****	−0.27 ± 0.10**	−0.50 ± 0.07****	−0.29 ± 0.08***
Lifetime GAD	−0.77 ± 0.07****	−0.34 ± 0.08****	−0.59 ± 0.09****	−0.34 ± 0.11**	−0.56 ± 0.08****	−0.24 ± 0.09*
Number of CD criteria	−0.25 ± 0.02****	−0.05 ± 0.02	−0.17 ± 0.03****	−0.08 ± 0.03*	−0.16 ± 0.02****	−0.09 ± 0.03***
Number of ASPD criteria	−0.44 ± 0.02****	−0.38 ± 0.02****	−0.18 ± 0.03****	−0.10 ± 0.03**	−0.18 ± 0.02****	−0.09 ± 0.02***
Novelty seeking # items	−0.04 ± 0.01****	−0.00 ± 0.01	−0.03 ± 0.01*	−0.00 ± 0.01	−0.04 ± 0.01****	−0.02 ± 0.01

FH – family history; ALC – alcohol use disorders; DA – drug abuse; MD – major depression; GAD – generalized anxiety disorder; CD – conduct disorder; ASPD – antisocial personality disorder.

Alcohol – N for univariate 5001–6025 (except for FH of DA – n = 4001), for multivariate 4500.

Nicotine – N for univariate analyses 3260–3640 (except for FH of DA – n = 2686), for multivariate n = 2950.

Nicotine – N for univariate analyses 2207–2450 (except for FH of DA – n = 1901), for multivariate n = 2050.

^*p < 0.05.

^**p < 0.01.

^***p < 0.001.

^****p < 0.0001.

^aincluding weight as a covariate.