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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: J Immunol. 2015 Aug 21;195(7):3284–3292. doi: 10.4049/jimmunol.1500683

Fig. 5. Diminished IL-12 and IFN-α production by mononuclear phagocytes from SIV infected lymph nodes.

Fig. 5

(A) Lymph node suspensions from naïve monkeys and monkeys with acute or chronic SIV infection were incubated with or without Env976 for 7 h with brefeldin A added in the final 5 h. Representative IFN-α and IL-12 production by pDC, mDC, and macrophages from SIV-naïve and acutely infected macaques are shown. (B) Quantification of the percentage of pDC, mDC, and macrophages producing IFN-α and IL-12 after stimulation with Env976 as determined by intracellular cytokine staining. Each symbol represents an individual animal. Capped bars signify differences found through repeated measures ANOVA and multiple comparisons tests. *P<0.05; **P< 0.01; ***P< 0.001