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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: J Immunol. 2015 Aug 17;195(7):3011–3019. doi: 10.4049/jimmunol.1402446

Figure 3.

Figure 3

IL2rγ-dependent receptors that can bind, but not induce cytokine signaling in host cells alter the engraftment of diabetogenic T-cells without blocking their activation.

Splenocytes (2.5×106) from NOD-AI4 TCR transgenic mice were injected i.v. into NSG (n=13), NOG (n=15) and NOD-scid (n=13) recipients. A) At 2 weeks post-transfer 3 mice of each recipient type were euthanized and SPL, PLN, and MLN were analyzed for total AI4 CD8+ T-cell numbers by flow cytometry. Bars represent mean ± SEM, Statistical analyses by two-way ANOVA with Bonferroni post-test correction. ns: p>0.05, * p<0.05, ** p<0.001. B) Ten mice of each recipient type were assessed for T1D incidence. Log-rank (Mantel-Cox) Test (*** p<0.0001).