Table I.
Chemokine and cytokine levels in serum of naïve WT and Il10−/− micea
| IL-23 (pg/ml) | IFN-γ (pg/ml) | TNF-α (pg/ml) | CCL2 (pg/ml) | IL-1β (pg/ml) | IP-10 (pg/ml) | IL-6 (pg/ml) | IL-17 (pg/ml) | |
|---|---|---|---|---|---|---|---|---|
| WT | ||||||||
| 1 | nd | nd | nd | 12.8 | nd | 9.8 | 19.4 | 9.8 |
| 2 | nd | nd | nd | 52.15 | nd | 5.67 | 193.4 | nd |
| 3 | nd | 8.7 | 6.7 | 294.6 | 8.27 | 17.14 | 655.3 | 6.5 |
| 4 | nd | 9.4 | 11.7 | 17.3 | nd | 9.94 | 21.7 | 29.5 |
|
| ||||||||
| Mean ± SE | na | 9.0 ± 0.4 | 9.2 ± 2.5 | 94.2 ± 67.4 | na | 10.6 ± 2.4 | 222.4 ± 149.9 | 15.3 ± 7.2 |
|
| ||||||||
| Il10−/− | ||||||||
| 1 | 6.1 | 49.68 | 15.5 | 15.4 | 16.45 | 33.77 | 257.5 | 52.9 |
| 2 | 6.2 | 25.2 | 17.1 | 19.6 | 21.79 | 21.81 | 61.8 | 20.4 |
| 3 | nd | 39.2 | 11.4 | 13.0 | nd | 25.7 | 253.2 | 31.4 |
| 4 | nd | nd | nd | 630 | nd | 55.4 | 330.4 | nd |
|
| ||||||||
| Mean ± SE | 6.2 ± 0.03 | 38.1 ± 7.1 | 14.6 ± 1.7 | 169.5 ± 153.5 | 19.1 ± 2.7 | 34.2 ± 7.5 | 225.7 ± 57.4 | 34.9 ± 9.5 |
a
Mice aged 7–8 weeks.
nd: not detected; na: not applicable