Table 1.

Molecules implicated in the pathogenesis of inflammatory neuropathies

	AIDP	CIDP	NSVN
Peripheral Nerve	C3d, C5b-C9, immunoglobulin, MHC Class II, TNF-α, IL-1β, IFN-γ, MMP-9, ICAM- 1, CCL2, CXCL10, β4 integrin, CR1, CD80, ICOS, ICOS-L, NF-κB, I-κB, IL-23p19, Fcγ, macrophage differentiation markers (MRP14, 27E10), CCR1, CCR2, CCR4, CCR5, CXCR3	HLA-DR, TNF-α, IFN- γ, IL-1, IL-2, IL-6, CD58, CD74, ICAM-1, E-selectin, CXCL10, Claudin-5, MMP-2, MMP-9, γδ-T cells, CD73, Macrophage differentiation markers (MRP8, 25F9), CD80, NF-κB, ICOS, ICOS-L, CCR1, CCR2, CCR4, CCR5, CXCR3	Complement, immunoglobulin, fibrinogen, HLA class I and II, CD58, CD86, IL1-β, IL-6, TNF-α, MMP-2, MMP-9, ICOS, ICOS-L, AIF-1, HIF-1α, HIF-1β, HIF- 2α, VEGF, VEGF-R, NGF, erythropoietin- receptor, GDNF, CNTF, NF-κB, RAGE, RAGE ligand N(ε)- (carboxymethyl) lysine, granzyme A, granzyme B and T- cell restricted intracellular antigen, Fas, FasL
Cerebrospinal fluid/ Plasma/ Serum	TNF-α, IL-1β, IFN-γ, IL- 1RA, IL-2, IL-6, IL-12, IL-17, IL-18, IL-22, IL- 37, neopterin, osteopontin, ICAM-1, VCAM-1, E-selectin, α6β4 integrin, VEGF, hypocretin-1, CCL2, CCL7, CCL27, CXCL9, CXCL10, CXCL12, S100β, phosphorylated neurofilament heavy chain protein and tau	IL-5, IL-6,IL-12, IL-17, growth arrest specific 6, MMP-2, cathepsin B, cystatin C, CCL2, CCL3, CCL7, CCL19, CCL27, CXCL9, CXCL10, CXCL12, ICAM-1, VCAM1, VEGF, SCF, HGF, IFN-γ+ IL-4- CD4+ T cells, intracellular IFN-γ/IL-4 ratio	VEGF, IL-6, IL-8, IL- 10
Cerebrospinal fluid/ Nerve Microarray or Proteomics	vitamin D-binding protein, beta-2 glycoprotein I, complement component C3 isoform, haptoglobin, apolipoprotein A-IV, PRO2044, serine/threonine kinase 10,alpha spectrin II, IgG heavy chain, SNC73 protein, cathepsin D preprotein, serine proteinase inhibitor, cystatin C, transthyretin, albumin, apolipoprotein E, caldesmon 1 isoform, UDP glucose-hexose- 1-phosphate uridyltransferase, HSP70, amyloidosis patient HI heart peptide, transferrin	tachykinin precursor 1, CD69, stearoyl-co- enzyme A, CXCL9, desaturase, HLA- DQB1, AIF-1, macrophage scavenger receptor 1, PDZ and LIM domain 5, CCR2, mast cell carboxypeptidase 3, alpha-1 acid glycoprotein 1 precursor transferrin, apolipoprotein A IV, haptoglobin, transthyretin, retinol binding protein, pro- apolipoprotein, integrin β8	AIF-1, immunoglobulin lambda joining 3, immunoglobulin heavy constant gamma 3, immunoglobulin kappa constant, immunoglobulin lambda locus, CXCL9, CCR2 and CX3CR1, Krüppel- Like Transcription Factors KLF2, KLF4, nuclear orphan receptor NR4A1

Bold indicates reduced levels compared to unaffected patients or healthy controls