Figure 6. In vivo CD4 T cell cytotoxicity is independent of canonical cytolytic pathways.

(A) WT and FasL^−/− immunized mice both kill MHCII⁺ CD45.1 cells. (B) WT and Pfr^−/− immunized mice both kill CD45.1 and Fas^−/− MHCII⁺ WT cells. (C) WT and Pfr^−/− immunized mice kill CD45.1 and DR5^−/− MHCII⁺ target cells. (D) WT immunized mice kill WT, Casp3^−/−, Casp7^−/−, Bax^−/− and TNFR1/2^−/− MHCII⁺ targets. N=5 animals/group. Data are representative of two to five experiments with similar results. Bars represent mean + s.d.