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. Author manuscript; available in PMC: 2016 Sep 17.
Published in final edited form as: Mol Cell. 2015 Sep 10;59(6):1011–1024. doi: 10.1016/j.molcel.2015.07.029

Fig. 7. Modeling the roles for ATR, DNA-PK, and Chk1 in countering replication stress.

Fig. 7

A. A fraction of early S-phase cells are particularly vulnerable to ATR inactivation. B. ATRi selectively kills cells under high replication stress, whereas Chk1i induces cell death even in cells in which replication stress is moderate. C. ATRi-induced ssDNA is an indicator of replication stress that may predict the ATRi sensitivity of cancer cells.