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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: Arch Biochem Biophys. 2015 Aug 14;583:96–104. doi: 10.1016/j.abb.2015.08.005

Figure 1.

Figure 1

Glutathione-dependent metabolites of busulfan. A) The GSH adduct of busulfan rearranges to the GS-THT+, which subsequently undergoes β-elimination to EdAG. B) EdAG undergoes additional reaction with GSH to form GSG.