Table 1.

Characteristics of the animal groups at the moment of the sacrifice

	A	B	C
Parameters	Wild-type rats	PCK Rats (non-treated)	PCK Rats (UDCA-treated)	P value (A vs B)	P value (B vs C)
Body weight (g)	675.9 ± 15.72	575.6 ± 12.42	573.8 ± 9.61	.0001 *	.91
Liver weight (g)	20.69 ± 0.95	32.68 ± 3.99	26.2 ± 2.28	.0045 *	.17
Liver/body weight (%)	3.09 ± 0.10	5.79 ± 0.82	4.598 ± 0.43	.003 *	.21
Kidney weight (g)	..............	2.71 ± 0.16	3.2 ± 0.64	.....	.46
Kidney/body weight (%)	..............	0.9 ± 0.1	1.0 ± 0.1	.....	.37
Bile flow (µL/min/g)	0.337 ± 0.03	0.76 ± 0.13	1.033 ± 0.10	.007 *	.13
Alkaline phosphatase (U/L)	89.83 ± 7.2	122.7 ± 13.96	117.9 ± 10.95	.04 *	.79
Aspartate aminotransferase (U/L)	149.1 ± 32.64	176.7 ± 36.32	159.3 ± 17.85	.57	.67
Alanine aminotransferase (U/L)	59.0 ± 6.68	48.6 ± 3.89	53.7 ± 5.02	.20	.43
Albumin (g/L)	3.8 ± 0.05	2.04 ± 0.09	1.99 ± 0.06	.0001 *	.66
Protein total (g/dL)	5.65 ± 0.08	4.13 ± 0.08	3.88 ± 0.05	.0001 *	.02*
Bilirubin total (mg/dL)	..............	0.16 ± 0.0	0.17 ± 0.0	.....	.67
Blood urea (mg/dL)	33.6 ± 1.3	36.27 ± 2.5	33.6 ± 2.8	.35	.49

“Dot lines” indicate non-analyzed values