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. 2015 Jul;6(7-8):288–302. doi: 10.18632/genesandcancer.73

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Copyright: © 2015 Thakur and Chen

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Paradoxical role of mdig/MINA in cell proliferation, motility and invasion. It promotes cell proliferation whereas exerts inhibitory effects on migration and invasion. In the immune system, mdig/MINA positively regulates Th17 differentiation while inhibits Foxp3 programs shutting the production of Treg cells. It negatively regulates the IL-4 production thereby reducing the Th2 cell-mediated immune response.