Table 2. Genotype frequencies of polymorphisms in lung cancer cases and controls.
| Polymorphism/genotype | Cases* (%) | Controls* (%) | P† | Adjusted OR (95% CI)‡ | P‡ | q value |
|---|---|---|---|---|---|---|
| rs2853669 T > C | ||||||
| TT | 478 (43.8) | 485 (44.9) | 0.11 | 1.00 | ||
| TC | 477 (43.7) | 490 (45.4) | 0.99 (0.82-1.18) | 0.96 | 0.85 | |
| CC | 137 (12.5) | 105 (9.7) | 1.37 (1.03-1.83) | 0.03 | 0.18 | |
| TT+TC | 955 (87.5) | 975 (90.3) | 0.04 | 1.00 | ||
| CC | 137 (12.5) | 105 (9.7) | 1.38 (1.05-1.81) | 0.02 | 0.05 | |
| rs2736108 G > A | ||||||
| GG | 619 (57.3) | 618 (58.0) | 0.43 | 1.00 | ||
| GA | 382 (35.3) | 384 (36.0) | 0.99 (0.82-1.19) | 0.89 | 0.89 | |
| AA | 80 (7.4) | 64 (6.0) | 1.30 (0.92-1.85) | 0.14 | 0.34 | |
| GG+GA | 1001 (92.6) | 1002 (94.0) | 0.20 | 1.00 | ||
| AA | 80 (7.4) | 64 (6.0) | 1.31 (0.93-1.85) | 0.12 | 0.13 | |
| rs2736098 G > A | ||||||
| GG | 499 (45.6) | 487 (46.1) | 0.13 | 1.00 | ||
| GA | 465 (42.5) | 472 (44.7) | 0.96 (0.80-1.16) | 0.69 | 0.67 | |
| AA | 130 (11.9) | 98 (9.3) | 1.35 (1.00-1.80) | 0.05 | 0.19 | |
| GG+GA | 964 (88.1) | 959 (90.7) | 0.05 | 1.00 | ||
| AA | 130 (11.9) | 98 (9.3) | 1.37 (1.04-1.81) | 0.03 | 0.05 | |
| rs7705526 C > A | ||||||
| CC | 418 (39.6) | 433 (41.1) | 0.64 | 1.00 | ||
| CA | 474 (44.9) | 470 (44.6) | 1.05 (0.87-1.27) | 0.62 | 0.66 | |
| AA | 164 (15.5) | 150 (14.2) | 1.16 (0.89-1.50) | 0.28 | 0.54 | |
| CC+CA | 892 (84.5) | 903 (85.8) | 0.41 | 1.00 | ||
| AA | 164 (15.5) | 150 (14.2) | 1.13 (0.89-1.44) | 0.33 | 0.33 | |
| rs2293607 G > A | ||||||
| GG | 401 (37.3) | 406 (38.6) | 0.82 | 1.00 | ||
| GA | 514 (47.8) | 491 (46.6) | 1.06 (0.88-1.28) | 0.53 | 0.65 | |
| AA | 161 (15.0) | 156 (14.8) | 1.07 (0.82-1.39) | 0.63 | 0.66 | |
| GG+GA | 915 (85.0) | 897 (85.2) | 0.92 | 1.00 | ||
| AA | 161 (15.0) | 156 (14.8) | 1.03 (0.81-1.31) | 0.80 | 0.80 | |
| rs412658 C > T | ||||||
| CC | 400 (38.2) | 401 (38.4) | 0.46 | 1.00 | ||
| CT | 500 (47.8) | 478 (45.8) | 1.07 (0.89-1.29) | 0.48 | 0.65 | |
| TT | 146 (14.0) | 164 (15.7) | 0.91 (0.70-1.19) | 0.51 | 0.65 | |
| CC+CT | 900 (86.0) | 879 (84.3) | 0.26 | 1.00 | ||
| TT | 146 (14.0) | 164 (15.7) | 0.88 (0.69-1.12) | 0.31 | 0.31 |
*Numbers may not add up total number of patients due to genotype failures; †P value for chi-square test; ‡ORs, 95% CIs and their corresponding P values were calculated using multivariate regression analysis, adjusted for age, gender, and pack-years smoking. OR, odds ratio; CI, confidence interval.