Table 3. Mortality and neonatal morbidities of very low birth weight infants with histologic chorioamnionitis defined based on the site of inflammation.
| Parameters | Any HC | Amnionitis | Funisitis | Amnionitis + funisitis | ||||
|---|---|---|---|---|---|---|---|---|
| + (n = 99) |
- (n = 159) |
+ (n = 19) |
- (n = 239) |
+ (n = 34) |
- (n = 224) |
+ (n = 13) |
- (n = 245) |
|
| Mortality (%) | 8 (8.1) | 17 (10.7) | 1 (5.3) | 24 (10.0) | 3 (8.8) | 22 (9.8) | 1 (7.7) | 24 (9.8) |
| RDS (%) | 57/99 (57.6) | 90/159 (61.2) | 8/19 (42.1) | 139/239 (58.2) | 17/34 (50.0) | 130/224 (58.0) | 5/13 (38.5) | 142/245 (58.0) |
| BPD (%) | 28/92 (30.4) | 32/142 (22.5) | 9/18 (50.0)* | 51/216 (23.6) | 9/31 (29.0) | 51/203 (25.1) | 4/12 (33.3) | 56/222 (25.2) |
| NEC (%) | 6/93 (6.5) | 10/145 (6.9) | 1/18 (5.6) | 15/220 (6.8) | 3/31 (9.7) | 13/207 (6.3) | 1/12 (8.3) | 15/226 (6.6) |
| IVH ≥Gr 3 (%) | 7/92 (7.6) | 6/143 (4.2) | 0/18 (0) | 13/217 (6.0) | 3/31 (9.7) | 10/204 (4.9) | 0/12 (0) | 13/223 (5.8) |
| PVL (%) | 5/92 (5.4) | 12/143 (8.4) | 0/18 (0) | 17/217 (7.8) | 3/31 (9.7) | 14/204 (6.9) | 0/12 (0) | 17/223 (7.6) |
| EOS (%) | 1/94 (1.1) | 2/148 (1.4) | 0/18 (0) | 3/224 (1.3) | 0/32 (0) | 3/210 (1.4) | 0/12 (0) | 3/230 (1.3) |
| LOS (%) | 8/92 (8.7) | 14/144 (9.7) | 3/18 (16.7) | 19/218 (8.7) | 1/31 (3.2) | 21/205 (10.2) | 1/12 (8.3) | 21/224 (9.4) |
| Severe ROP (%) | 26/92 (28.3)* | 24/143 (16.8) | 6/18 (33.3) | 44/217 (20.3) | 11/31 (35.5)* | 39/204 (19.1) | 3/12 (25.0) | 47/223 (21.1) |
| Laser surgery (%) | 23/92 (25.0)* | 16/142 (11.3) | 5/18 (27.8) | 34/216 (15.7) | 9/31 (29.0)* | 30/203 (14.8) | 3/12 (25.0) | 36/222 (16.2) |
*P<0.05. HC, histologic chorioamnionitis; BPD, bronchopulmonary dysplasia; EOS, early onset sepsis; IVH, intraventricular hemorrhage; LOS, late onset sepsis; NEC, necrotizing enterocolitis; PVL, periventricular leukomalacia; RDS, respiratory distress syndrome; ROP, retinopathy of prematurity.