Table 3. Univariate and multivariate Cox regression models for the prediction of overall mortality in patients treated with radical nephroureterectomy for upper tract urothelial carcinoma.
| Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95%, CI) | P value | HR (95%, CI) | P value | |
| Age (continuous) | 1.027 (1.004-1.050) | 0.021 | 1.019 (0.994-1.045) | 0.139 |
| Gender (female) | 1.000 (0.635-1.576) | 1.000 | ||
| ASA-PS score (≥ 3) | 2.084 (1.150-3.776) | 0.015 | 1.981 (1.057-3.711) | 0.033 |
| BMI (continuous) | 0.914 (0.853-0.979) | 0.010 | 0.922 (0.853-0.998) | 0.045 |
| Smoking history (yes) | 0.994 (0.612-1.614) | 0.980 | ||
| Tumor size (continuous) | 1.009 (1.003-1.015) | 0.004 | 1.005 (0.998-1.012) | 0.199 |
| Multiplicity (yes) | 1.590 (1.028-2.458) | 0.037 | 1.665 (0.939-2.952) | 0.081 |
| Pathologic T stage (≥ T3) and/or N stage (N1-2) | 3.025 (1.734-5.278) | < 0.001 | 1.964 (1.009-3.824) | 0.047 |
| Grade (high) | 2.723 (1.478-5.018) | 0.001 | 1.774 (0.861-3.658) | 0.120 |
| Concomitant CIS (yes) | 0.757 (0.275-2.085) | 0.591 | ||
| Lymphovascular invasion (yes) | 3.198 (2.061-4.960) | < 0.001 | 2.400 (1.469-3.921) | < 0.001 |
| Margin status (positive surgical margin) | 4.178 (2.256-7.738) | < 0.001 | 2.478 (1.261-4.871) | 0.008 |
| Adjuvant chemotherapy (yes) | 1.799 (1.108-2.921) | 0.017 | 1.407 (0.776-2.550) | 0.261 |
HR, hazard ratio; CI, confidence interval; ASA-PS, American Society of Anesthesiologists Physical Status; BMI, body mass index; CIS, carcinoma in situ.