Radiobiological parameters in the following table are used to estimate the equivalent uniform dose (EUD) and tumor control probability (TCP) for principal structures.
| Type | Radiobiological parameters | |||||
|---|---|---|---|---|---|---|
| Cancer cell/Organs | α/β* | TCD50†/TD50‡ | a§ | γ50∥ | End point | |
| Target | High grade glioma (Primary culture) | 10 | 72.7 | -10 | 1.5 | Local control |
| Normal tissues | Brain | 3 | 60 | 5 | 3 | Necrosis |
| Brainstem | 65 | 7 | 3 | Necrosis | ||
| Optic Chiasm | 65 | 25 | 3 | Blindness | ||
| Lens | 18 | 3 | 1 | Cataract | ||
| Optic Nerve | 65 | 25 | 3 | Blindness | ||
| Retina | 65 | 15 | 2 | Blindness | ||
*α/β, linear and quadratic term in dose at linear quadratic model of cell survival curve; †TCD50, required dose for 50% control probability of tumor; ‡TD50, radiation dose that results in a 50% severe complication rate of normal tissues; §a, biological model parameter to calculate equivalent uniform dose; ∥γ50, normalized slope at the 50% tumor control probability.