Table 1. Proteomic examples of autoantigens found in cultured TECs and TEC-derived exosomes (cultures 1 and 2).

Protein	Gene	Associated disease	Present in cells	Present in exosomes	TRA	Ref.
Collagen type II	COL2A	Rheumatoid arthritis	Yes	No	Yes	32
Desmoglein 1 and 3	DSG1, DSG3	Pemphigus vulgaris	No, Yes	Yes, Yes	Yes, Yes	33
Alpha-Enolase	ENOA	Various; RA, peridontitis, hypophysitis	Yes	Yes	No	34, 35, 36
Titin	TTN	Myasthenia gravis	Yes	No	Yes	37
Laminin gamma 1	LAMC1	Pemphigoid	Yes	Yes	No	38
Collagen 17	COL17A1	Bullous pemphigoid	Yes	Yes	Yes	39
Vinculin	VCL	Systemic sclerosis	Yes	Yes	Yes	40
Galectin 1, 3 and 7	LGALS1, LGALS3, LGALS7	SLE	Yes, Yes, Yes	Yes, No, No	No, No, Yes	41, 42
Heat-shock protein 60	HSPD1	Various; Vasculitis, T1D, RA	Yes	Yes	No	43
Tissue transglutaminase 2	TGM2	Coeliac disease	nd	Yes	Yes	20
Myelin basic protein	MBP	Multiple sclerosis	nda	Yes	Yes	44

Abbreviations: nd, not determined; RA, rheumatoid arthritis; SLE, systemic lupus erythematosus; T1D, type 1 diabetes; TEC, thymic epithelial cell; TRA, tissue-restricted antigen.

^aMBP encoding mRNA is present in cells of origin.