Table 2.

Review articles on TXA use in trauma.

Title	Author(s)	Description	Year	Critique
Tranexamic Acid for Trauma Patients: A Critical Review of the Literature [14]	Cap et al.	Systematic review of TXA	2011	Favorable towards CRASH-2 findings and recommends use in combat situations and bleeding trauma patients
Tranexamic Acid and Trauma: Current Status and Knowledge Gaps with Recommended Research Priorities [15]	Pusateri et al., Department of Defense	Systematic review of TXA	2013	Identifies “knowledge gaps” in the CRASH-2 trial: (1) lack of clarity of reporting of monitoring, complications, (2) no transfusion benefit, and (3) data not robust
Tranexamic Acid in Trauma: How Should We Use It? [16]	Napolitano et al.	Systematic review of TXA	2013	Major knowledge gaps: (1) recruitment, (2) 100% follow-up, (3) 50% received transfusion, (4) survival benefit not a function of transfusion, (5) TBI greatest cause of death, (6) low rate of thrombosis, and (7) other shortcomings noted